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Tank Top Reviews (139)

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Like a group of barnacles hanging onto a rock, these human cells hang onto a matrix coated glass slide. Actin stress fibers, stained magenta, and the protein vinculin, stained green, make this adhesion possible. The fibroblast nuclei are stained blue. Researchers used the meeting point of these two molecules, known as focal adhesions, to develop a new way of isolating human induced pluripotent stem (iPS) cells. These cells are specialized tissue or organ cells that have been reprogrammed into a stem cell-like state and can become just about any cell type. Understanding and harnessing this cellular reprogramming could aid the development of therapies for replacing defective or diseased cells. One time-consuming challenge is the process of separating the stem cells from the other cells in a culture. Less than 1 percent of the starting human cells become reprogrammed to iPS cells. Isolating them is akin to finding the proverbial needle in a haystack - only these needles are cell colonies...

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